Unbeatable, led by comedian Jason Manford, 42, is coming to an end after two seasons.
First launched in 2021, the program puts players in front of a question and selecting from a board of six sortable answers, in the hope of finding the unbeatable one and depositing £1,000.
However, the BBC decided not to renew Unbeatable for a third season to free up funds for more new content.
A BBC spokesperson said TVZoneUK: 'Unbeatable had two great series but we need to make room for new opportunities.
“We would like to thank Jason and the team for all their hard work.”
The cancellation comes after the Beeb canceled the Christmas University Challenge episode after being accused of 'ableism' by two contestants, who had flagged disability to producers before the program said it was not accessible to them.
According to BBC Newsone participant in the episode – filmed in November – is blind, while the other is neurodivergent.
It is understood that audio description was not provided, despite assurances that it would be, while a request for subtitles for the neurodivergent contestant was denied.
Affected contestants complained to the BBC and requested that the episode not be broadcast, with one saying he 'would prefer not to have the manifestation of my disability broadcast'.
Approached for comment, a BBC spokesperson told Metro.co.uk: 'We can confirm that an episode of the upcoming series of Alumni University Challenge will not be broadcast as two of the contestants felt their access requirements were not sufficiently met by the production .
'We are working closely with producers to improve access across industries…our programs to ensure a consistent approach is implemented.
“We would like to apologize to the individuals and crews involved, and they have been sent personally by the producers.”
Producer Lifted Entertainment said: “During the pre-filming briefing for this episode, two contestants requested that certain adjustments be made so that they could fully participate.
'However, after recording, we were informed that the adjustments made fell short of their needs. We have spoken to the people involved and offered our sincere apologies.
'Having listened carefully to descriptions of their experiences, we agreed with the BBC that the fairest course of action would be not to show this particular edition.'
The BBC isn't the only broadcaster to make cuts recently – with ITV too eliminating two celebrity-led game shows.
In October, it was reported that the network had decided to get rid of Sitting On A Fortune, hosted by Gary Lineker, 62, and Moneyball, hosted by Ian Wright, 59, from its programming.
Metro.co.uk has contacted the BBC for comment.
Unbeatable is available to stream on BBC iPlayer.
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